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Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition.

McKenzie CristBenyamin YanivSarah PalackdharryMaria A LehnMario MedvedovicTimothy StoneShuchi GulatiVidhya KariveduMichael BorchersBethany FuhrmanAudrey CragoJoseph CurryUbaldo Martinez-OutschoornVinita TakiarTrisha M Wise-Draper
Published in: Journal for immunotherapy of cancer (2022)
Our data identifies a new role for metformin-mediated immune antitumorigenic function through NK cell-mediated cytotoxicity and downregulation of CXCL1 in HNSCC. These findings will inform future immunomodulating therapies in HNSCC.
Keyphrases
  • nk cells
  • single cell
  • cell proliferation
  • cell therapy
  • genome wide
  • electronic health record
  • signaling pathway
  • current status
  • stem cells
  • machine learning
  • bone marrow
  • mesenchymal stem cells
  • artificial intelligence