Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition.
McKenzie CristBenyamin YanivSarah PalackdharryMaria A LehnMario MedvedovicTimothy StoneShuchi GulatiVidhya KariveduMichael BorchersBethany FuhrmanAudrey CragoJoseph CurryUbaldo Martinez-OutschoornVinita TakiarTrisha M Wise-DraperPublished in: Journal for immunotherapy of cancer (2022)
Our data identifies a new role for metformin-mediated immune antitumorigenic function through NK cell-mediated cytotoxicity and downregulation of CXCL1 in HNSCC. These findings will inform future immunomodulating therapies in HNSCC.