VE-cadherin cleavage in sleep apnoea: new insights into intermittent hypoxia-related endothelial permeability.

Olfa HarkiRenaud TamisierJean-Louis PépinJean-François TimsitAnissa MahmaniBrigitte GonthierAude SalomonIsabelle VilgrainGilles FauryAnne Briançon-Marjollet

Published in: The European respiratory journal (2021)

We suggest that in OSA, intermittent hypoxia increases endothelial permeability in OSA by inducing VE-cadherin cleavage through reactive oxygen species production, and activation of HIF-1, VEGF and tyrosine kinase pathways.

Keyphrases

endothelial cells
tyrosine kinase
positive airway pressure
obstructive sleep apnea
reactive oxygen species
epidermal growth factor receptor
vascular endothelial growth factor
high intensity
dna binding
cell migration
sleep apnea
cell adhesion
physical activity
sleep quality
depressive symptoms