Hematopoietic stem cells and metabolic deterioration in Alström syndrome, a rare genetic model of the metabolic syndrome.
Francesca DassieMattia AlbieroSilvia BettiniRoberta CappellariGabriella MilanStefano CiciliotJurgen K NaggertAngelo AvogaroRoberto VettorPietro MaffeiGian Poalo FadiniPublished in: Endocrinology (2023)
We found depletion of HSPCs in AS patients, which was recapitulated in Alms1-mutated mice. Larger and longer studies will be needed to establish HSPCs shortage as a driver of metabolic deterioration leading to end-organ damage in AS.
Keyphrases
- metabolic syndrome
- end stage renal disease
- ejection fraction
- induced apoptosis
- newly diagnosed
- chronic kidney disease
- oxidative stress
- prognostic factors
- peritoneal dialysis
- cell cycle arrest
- insulin resistance
- genome wide
- gene expression
- case report
- cardiovascular disease
- uric acid
- endoplasmic reticulum stress
- cell proliferation
- cardiovascular risk factors
- pi k akt