Beta cell endoplasmic reticulum stress drives diabetes in the KINGS mouse without causing mass beta cell loss.

Lydia F Daniels GatwardYujin KimAerin LoeYiyang LiuLine KristensenAileen J F King

Published in: Diabetic medicine : a journal of the British Diabetic Association (2022)

We propose that the KINGS mouse represents a model where beta cell maladaptive UPR signalling drives diabetes development without causing mass beta cell loss.

Keyphrases

single cell
endoplasmic reticulum stress
cell therapy
type diabetes
cardiovascular disease
stem cells
metabolic syndrome
oxidative stress
signaling pathway
insulin resistance