Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis.

Pedro A Ruiz CastroUlrike KogelGiuseppe Lo SassoBlaine W PhillipsAlain SewerBjorn TitzLlenalia GarciaAthanasios KondylisEmmanuel GuedjDariusz PericDavid BornandRemi DulizeCeline MergMaica CorciuloNikolai V IvanovManuel C PeitschJulia Hoeng

Published in: Journal of inflammation (London, England) (2020)

Our results support the amelioration of inflammatory effects by anatabine in the DSS mouse model of UC, and suggest that anatabine constitutes a promising therapeutic agent for IBD treatment.

Keyphrases

mouse model
oxidative stress
ulcerative colitis
combination therapy
replacement therapy