Biomarkers to discriminate between aseptic loosened and stable total hip or knee arthroplasties: a systematic review.
Shaho HasanPeter van SchieBart L KapteinJan W SchoonesPerla J Marang-van de MheenRob R G H H NelissenPublished in: EFORT open reviews (2024)
Several serum and urine markers were promising in discriminating between loosened and stable implants. We recommend future studies to evaluate these biomarkers in a longitudinal fashion to assess whether progression of loosening is associated with a change in these biomarkers. In particular, high-quality studies assessing the usability of these biomarkers are needed.