Effects of a new β3-adrenoceptor agonist, vibegron, on neurogenic bladder dysfunction and remodeling in mice with spinal cord injury.

Daisuke GotohNobutaka ShimizuNaoki WadaKatsumi KadekawaTetsuichi SaitoShinsuke MizoguchiYosuke MorizawaShunta HoriMakito MiyakeKazumasa TorimotoWilliam C de GroatKiyohide FujimotoNaoki Yoshimura

Published in: Neurourology and urodynamics (2020)

Vibegron reduced NVCs, delayed the first NVC, and improved collagen types 1 and 3, TGF-β1, and HIF-1α mRNA expression in SCI mice. Vibegron might be effective for SCI-induced LUTD.

Keyphrases

spinal cord injury
high fat diet induced
oxidative stress
high glucose
diabetic rats
transforming growth factor
type diabetes
insulin resistance