Essential Gene Knockdowns Reveal Genetic Vulnerabilities and Antibiotic Sensitivities in Acinetobacter baumannii .

Ryan D WardJennifer S TranAmy B BantaEmily E BaconWarren E Rose Jason M Peters

Published in: bioRxiv : the preprint server for biology (2023)

physiology and may represent appealing drug targets. We also find antibiotic-gene interactions that may impact the efficacy of carbapenems, rifamycins, and polymyxins, providing a new window into how these antibiotics function in mono- and combination therapies. Our studies offer a useful approach for characterizing interactions between drugs and essential genes in pathogens to inform future therapies.

Keyphrases

genome wide
acinetobacter baumannii
copy number
genome wide identification
multidrug resistant
dna methylation
drug resistant
pseudomonas aeruginosa
gram negative
genome wide analysis
current status
gene expression
emergency department
single cell
cystic fibrosis
electronic health record