Epigenetic aging in older breast cancer survivors and non-cancer controls: preliminary findings from the Thinking and Living with Cancer (TLC) Study.

Kelly E Rentscher Traci N BetheaWanting ZhaiBrent J SmallXingtao ZhouTim A AhlesJaeil AhnElizabeth C BreenHarvey Jay CohenMartine ExtermannDeena M A GrahamHeather S L JimBrenna C McDonaldZev M Nakamura Sunita J PatelJames C RootAndrew J SaykinKathleen M Van Dyk Jeanne S Mandelblatt Judith E Carroll

Published in: Cancer (2023)

Older breast cancer survivors, particularly those exposed to chemotherapy, showed greater epigenetic aging than controls that may relate to worse outcomes. If replicated, measurement of biological aging could complement geriatric assessments to guide cancer care for older women.

Keyphrases

papillary thyroid
dna methylation
squamous cell
gene expression
middle aged
locally advanced
lymph node metastasis
squamous cell carcinoma
metabolic syndrome
adipose tissue
childhood cancer
skeletal muscle
radiation therapy
rectal cancer