CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand.
Emily M RussellJenna C CarlsonMohanraj KrishnanNicola L HawleyGuangyun SunHong ChengTake NaseriMuagututi'a Sefuiva ReupenaSatupa'itea VialiJohn TuiteleTanya J MajorIva MiljkovicTony R MerrimanRanjan DekaDaniel E WeeksStephen T McGarveyRyan L MinsterPublished in: BMJ open diabetes research & care (2022)
There may be a stronger effect of BMI on fasting glucose in Polynesian individuals without obesity than in those with obesity. Carrying the rs373863828 minor allele does not decouple higher BMI from higher odds of type 2 diabetes.