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Record Ultralarge-Pores, Low Density Three-Dimensional Covalent Organic Framework for Controlled Drug Delivery.

Yu ZhaoSaikat DasTaishu SekineHaruna MabuchiTsukasa IrieJin SakaiDan WenWeidong ZhuTeng BenYuichi Negishi
Published in: Angewandte Chemie (International ed. in English) (2023)
The unique structural characteristics of three-dimensional (3D) covalent organic frameworks (COFs) like high surface areas, interconnected pore system and readily accessible active sites render them promising platforms for a wide set of functional applications. Albeit promising, the reticular construction of 3D COFs with large pores is a very demanding task owing to the formation of interpenetrated frameworks. Herein we report the designed synthesis of a 3D non-interpenetrated stp net COF, namely TUS-64, with the largest pore size of all 3D COFs (47 Å) and record-low density (0.106 g cm -3 ) by reticulating a 6-connected triptycene-based linker with a 4-connected porphyrin-based linker. Characterized with a highly interconnected mesoporous scaffold and good stability, TUS-64 shows efficient drug loading and controlled release for five different drugs in simulated body fluid environment, demonstrating the competency of TUS-64 as drug nanocarriers.
Keyphrases
  • drug delivery
  • cancer therapy
  • photodynamic therapy
  • drug release
  • drug induced
  • metal organic framework
  • adverse drug
  • emergency department
  • quantum dots
  • electron transfer