Ni-catalyzed non-activated C-S bond cleavage at ambient temperature for the synthesis of sulfur-containing polycyclic compounds.
Takanori ShibataAyato SekineMika AkinoMamoru ItoPublished in: Chemical communications (Cambridge, England) (2021)
A Ni-catalyzed intramolecular reaction of diarylthioether-tethered 1,8-diynes gave sulfur-containing tetracyclic compounds at ambient temperature. The transformation was initiated by non-activated sp2 C-S bond cleavage along with consecutive alkyne insertions. A double intramolecular reaction of a tetrayne and an intermolecular reaction of monoynes were also available, and the corresponding polycyclic compounds were obtained. Moreover, the obtained cycloadduct showed photo-catalytic activity in benzylic oxidation.