Sudden blast phase in pediatric chronic myeloid leukemia-chronic phase with abnormal lymphoid blasts detected by flow cytometry at diagnosis: Can it be considered a warning sign?

Kalasekhar Vijayasekharan Gaurav ChatterjeeSubramaniam RamanathanGaurav Narula Prashant Ramesh Tembhare Papagudi G Subramanian Nikhil V PatkarSumeet GujralDhanalaxmi Shetty Shripad D Banavali

Published in: Cytometry. Part B, Clinical cytometry (2020)

Although a retrospective study with limited sample size, presence of ABLB detected on flow-cytometry in CML-CP patients, had a noticeable early conversion to CML-BC in our cohort. Incorporation of flow-cytometry in diagnostic work-up can provide useful insight regarding the behavior of pediatric CML-CP patients and guide therapy.

Keyphrases

flow cytometry
chronic myeloid leukemia
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
stem cells
patient reported outcomes
young adults
mesenchymal stem cells
bone marrow
patient reported
cell therapy