Electroencephalographic Correlates of Clinical Severity in the Natural history study of RTT and Related Disorders.
Joni N SabyPatrick J MulcaheyTimothy A BenkeSarika U PetersShannon M StandridgeDavid N LiebermanAlexandra P KeyAlan K PercyCharles A NelsonTimothy P L RobertsJeffrey Lorenz NeulEric D MarshPublished in: Annals of neurology (2024)
Overall, group comparisons reflected a greater predominance of lower versus higher frequency activity in participants with RTT, which is consistent with prior clinical interpretations of resting EEG in this population. The observed associations between the EEG power measures and clinical assessments and the repeatability of these measures underscore the potential for EEG to provide an objective measure of cortical function and clinical severity for RTT. ANN NEUROL 2024;96:175-186.