Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections.

Jelmer H van PuffelenBoris NovakovicLiesbeth van EmstDenise KooperTahlita C M ZuiverloonUrsula T H OldenhofJ Alfred WitjesTessel E GaleslootAlina VrielingKatja K H AbenLambertus A L M KiemeneyEgbert OosterwijkMihai G NeteaJoost L BoormansAntoine G van der HeijdenLeo A B JoostenSita H Vermeulen

Published in: Journal for immunotherapy of cancer (2023)

We conclude that BCG immunotherapy induces trained immunity in NMIBC patients and this may account for the protective effects against respiratory infections. The data of our gene-based association analysis suggest that a link between trained immunity and oncological outcome may exist. Future studies should further investigate how trained immunity affects the antitumor immune responses in BCG-treated NMIBC patients.

Keyphrases

muscle invasive bladder cancer
end stage renal disease
newly diagnosed
ejection fraction
immune response
chronic kidney disease
resistance training
peritoneal dialysis
prostate cancer
prognostic factors
machine learning
gene expression
dna methylation
copy number
radical prostatectomy