Sex-specific differences in cardiac function, inflammation and injury during early polymicrobial sepsis.
Sophie L M WalkerChand MuthooJenifer SanchezAna Gutierrez Del ArroyoGareth L AcklandPublished in: Intensive care medicine experimental (2022)
In early normovolaemic polymicrobial sepsis, a relative hyperdynamic response develops in male mice. Myocardial stress/injury after early sepsis is limited in females, with less cardiac infiltration of CD4 + leukocytes but independent of shedding of TNFα from peripheral circulating leukocytes.