Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion.
Nick HornigoldKaren R DunnRachel A CravenAlexandre ZougmanSebastian TrainorRebecca ShreeveJoanne BrownHelen SewellMichael ShiresMargaret KnowlesTsutomu FukuwatariEamonn R MaherJulie BurnsSelina BhattaraiMini MenonAlvis BrazmaGhislaine SceloLara FeulnerYasser RiazalhosseiniMark LathropAdrian HarrisPeter J SelbyRosamonde E BanksNaveen S VasudevPublished in: British journal of cancer (2020)
Widespread dysregulation of the KP is common in RCC and is likely to contribute to tumour immune evasion, carrying implications for effective therapeutic targeting of this critical pathway.