Single cell multi-omics of fibrotic kidney reveal epigenetic regulation of antioxidation and apoptosis within proximal tubule.

Zhejun ChenLiqing YeMinyan ZhuCong XiaJunfen FanHongbo ChenZhijian LiShan Mou

Published in: Cellular and molecular life sciences : CMLS (2024)

In conclusion, as we know oxidation and apoptosis are traumatic factors during fibrosis, thus enhancing antioxidation and inhibiting the Nfix-Ifi27 pathway to inhibit apoptosis could be a potential treatment for kidney fibrosis.

Keyphrases

single cell
endoplasmic reticulum stress
cell cycle arrest
oxidative stress
cell death
rna seq
spinal cord injury
signaling pathway
pi k akt
idiopathic pulmonary fibrosis
genome wide
systemic sclerosis
dna methylation