First-decade patient with colorectal cancer carrying both germline and somatic mutations in APC gene.

Yung-Sung YehYu-Tang ChangCheng-Jen MaChing-Wen HuangHsiang-Lin TsaiYi-Ting ChenJaw-Yuan Wang

Published in: BMC cancer (2017)

The rare genetic features of this 10-year-old patient might be the predisposing cause of pediatric CRC. Therefore, screening patients with early-onset CRC through clinical and genetic characterizations is suggested.

Keyphrases

early onset
copy number
genome wide
late onset
case report
dna methylation
gene expression
dna repair
oxidative stress
dna damage
transcription factor
genome wide analysis