Multimodal mucosal and systemic immune characterization of a non-human primate trachoma model highlights the critical role of local immunity during acute phase disease.
Elodie PauletVanessa ContrerasMathilde GalhautIda RosenkrandsMartin HollandMatthew BurtonJes DietrichAnne-Sophie GallouetNathalie BosquetFrancis RelouzatSébastien LangloisFrank FollmannRoger Le GrandMarc LabetoulleAntoine RousseauPublished in: PLoS neglected tropical diseases (2024)
Our NHP model accurately reproduces the clinical signs of acute trachoma, allowing for an accurate assessment of the local immune responses in infected eyes. A progressive immune response occurred for weeks after exposure to Ct, which subsided into a persistent innate immune response. An understanding of these local responses is the first step towards using the model to assess new vaccine and therapeutic strategies for disease prevention.
Keyphrases
- immune response
- toll like receptor
- endothelial cells
- computed tomography
- magnetic resonance imaging
- optical coherence tomography
- drug induced
- intensive care unit
- high resolution
- induced pluripotent stem cells
- contrast enhanced
- mass spectrometry
- ulcerative colitis
- hepatitis b virus
- respiratory failure
- preterm birth
- image quality
- gestational age