Revealing the role of SPP1 + macrophages in glioma prognosis and therapeutic targeting by investigating tumor-associated macrophage landscape in grade 2 and 3 gliomas.

Wenshu TangCario W S LoWei MaAnnie T W ChuAmy H Y TongBrian Hon-Yin Chung

Published in: Cell & bioscience (2024)

Our findings illuminated the molecular and cellular mechanisms that shape the immunosuppressive microenvironment in gliomas, providing novel insights into potential therapeutic targets. Furthermore, the developed prognostic model holds promise for predicting immunotherapy response and assisting in more precise risk stratification for glioma patients.

Keyphrases

end stage renal disease
high grade
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
patient reported outcomes
machine learning
artificial intelligence
deep learning