Non-invasive detection of orthotopic human lung tumors by microRNA expression profiling of mouse exhaled breath condensates and exhaled extracellular vesicles.
Megan I MitchellIddo Z Ben-DovChristina LiuTao WangRachel B HazanThomas L BauerJohannes ZakrzewskiKathryn DonnellyKar ChowJunfeng MaOlivier LoudigPublished in: Extracellular vesicles and circulating nucleic acids (2024)
This study is the first of its kind and demonstrates that lung tumor EVs are exhaled in mice and provide non-invasive biomarkers for detection of lung tumors.