Visualizing the effects of metformin on tumor growth, vascularity, and metabolism in head and neck cancer.

Aparajita VermaLaurie J RichVui King Vincent-ChongMukund Seshadri

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2018)

Our results provide, for the first time, direct in vivo evidence of Met-induced changes in tumor microenvironmental parameters in HNSCC xenografts. Our findings highlight the utility of multimodal functional imaging for non-invasive mapping of the effects of Met in HNSCC.

Keyphrases

high resolution
tyrosine kinase
pain management
high density
mass spectrometry