Restriction of Intravenous Fluid in ICU Patients with Septic Shock.
Tine S MeyhoffPeter B HjortrupJørn WetterslevPraleene SivapalanJon H LaakeMaria CronhjortStephan M JakobMaurizio CecconiMarek NalosMarlies OstermannManu MalbrainVille PettiläMorten H MøllerMaj-Brit N KjærTheis LangeChristian Overgaard-SteensenBjörn A BrandMarie Winther-OlesenJonathan O WhiteLars QuistBo WestergaardAndreas B JonssonCarl J S HjortsøNick MeierThomas S JensenJanus EngstrømLars NebrichNina C Andersen-RanbergJacob V JensenNeeliya A JosephLone M PoulsenLouise S HerløvChristoffer G SøllingSusan K PedersenKurt K KnudsenTherese S StraarupMarianne L VangHelle BundgaardBodil Steen RasmussenSøren R AagaardThomas HildebrandtLene RussellMorten H BestleMartin Schønemann-LundAnne C BrøchnerClaes F ElvanderSøren K L HoffmannMichael L RasmussenYvonne K MartinFredrik F FribergHerman SeterTayyba N AslamSigrid ÅdnøyPhilipp SeidelKristian StrandBror JohnstadEva Joelsson-AlmJens ChristensenChristian AhlstedtCarmen A PfortmuellerMartin SiegemundMassimiliano GrecoJaroslav RadějMiroslav KřížDoug W GouldKathy M RowanPaul R MounceyAnders Pernernull nullPublished in: The New England journal of medicine (2022)
Among adult patients with septic shock in the ICU, intravenous fluid restriction did not result in fewer deaths at 90 days than standard intravenous fluid therapy. (Funded by the Novo Nordisk Foundation and others; CLASSIC ClinicalTrials.gov number, NCT03668236.).