Delayed treatment of MS is associated with high CSF levels of IL-6 and IL-8 and worse future disease course.
Mario Stampanoni BassiEnnio IezziDoriana LandiFabrizia MonteleoneLuana GilioIlaria SimonelliAlessandra MusellaGeorgia MandolesiFrancesca De VitoRoberto FurlanAnnamaria FinardiGirolama A MarfiaDiego CentonzeFabio ButtariPublished in: Journal of neurology (2018)
Delayed diagnosis and treatment initiation are associated with higher CSF levels of IL-6 and IL-8 in RR-MS, leading to worsening disease course and poor response to treatments.