Continuous exposure to doxorubicin induces stem cell-like characteristics and plasticity in MDA-MB-231 breast cancer cells identified with the SORE6 reporter.

Nohemí Salinas-JazmínMaría Adriana Medina-MondragónJeannie Jiménez-LópezSandra Lucia Guerrero-RodríguezPatricia Cuautle-RodríguezMarco Antonio Velasco Velazquez

Published in: Cancer chemotherapy and pharmacology (2024)

The generation of chemoresistant cells that have characteristics of CSCs, after exposure to low concentrations of Dox, involves the differential expression of genes that have a clinical impact.

Keyphrases

breast cancer cells
stem cells
cell cycle arrest
induced apoptosis
drug delivery
genome wide
crispr cas
cell death
endoplasmic reticulum stress
cancer therapy
oxidative stress
dna methylation
cell proliferation
cell therapy
bone marrow
transcription factor