Endothelial RUNX3 controls LSEC dysfunction and angiocrine LRG1 signaling to prevent liver fibrosis.
Uttam OjhaSomi KimChang Yun RheeJihye YouYoon Ha ChoiSoo-Hyun YoonSoo Young ParkYu Rim LeeJong Kyoung KimSuk-Chul BaeYou Mie LeePublished in: Hepatology (Baltimore, Md.) (2024)
RUNX3 deficiency in the endothelium induces LSEC dysfunction, LRG1 secretion, and liver fibrosis progression. Therefore, endothelial RUNX3 is a crucial gatekeeping factor in LSECs, and profibrotic angiocrine LRG1 may be a novel target for combating liver fibrosis.