Has the trend in pancreatic cancer mortality in Spain started to slow down?

In both sexes ASMRs (all ages) increase significantly (p<0.05) during the study period (AAPC: 1.5% in men and 1.8% in women). The joinpoint analysis identifies a turning point in the trends in the late 1980s which delineates two periods: an initial period of significant increase followed by a period of slowing of the increase (APC: 0.9% and 1.4% in males and females respectively; p<0.05). In both sexes, a significant increase in ASMR (all ages) is observed in all ACs, except in Navarre where the rates remain stable in men. In men, three ACs (Galicia, Madrid and Navarra) show a point of inflexion in the time trend around the year 2000 (1999, 2000 and 2001 respectively) when rates, after a period of significant increase (ACs: 2.6%, 2.4%, and 2.4% respectively, p<0.05), stabilise (Galicia and Navarre) or slow down their increase (Madrid). In women, only Madrid shows a point of inflection in 1992 when, after a significant increase, rates slow down (1992-2021; APC:1.5%, p<0.05).  Conclusions: The upward trend in pancreatic cancer mortality in some ACs seems to have slowed (in both sexes in Madrid), stabilised (in men in Galicia and Navarre) or turned around (in men aged 30-64 in Navarre).