Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration.

Jing LiShengqi WangNeng WangYifeng ZhengBowen YangXuan WangJuping ZhangBo PanZhiyu Wang

Published in: Cell communication and signaling : CCS (2021)

This study not only provides preclinical evidence supporting the application of ADQ in inhibiting breast cancer metastasis but also sheds novel insights into TAM/CXCL1/NF-κB/FOXP3 signaling as a promising therapeutic target for Treg modulation and breast cancer immunotherapy. Video Abstract.

Keyphrases

signaling pathway
regulatory t cells
high glucose
oxidative stress
diabetic rats
stem cells
drug induced
pi k akt
mesenchymal stem cells
human milk
endothelial cells
toll like receptor
dendritic cells