Silver-Catalyzed Stereoselective Aminosulfonylation of Alkynes.
Yongquan NingQinghe JiPeiqiu LiaoEdward A AndersonXihe BiPublished in: Angewandte Chemie (International ed. in English) (2017)
A silver-catalyzed intermolecular aminosulfonylation of terminal alkynes with sodium sulfinates and TMSN3 is reported. This three-component reaction proceeds through sequential hydroazidation of the terminal alkyne and addition of a sulfonyl radical to the resultant vinyl azide. The method enables the stereoselective synthesis of a wide range of β-sulfonyl enamines without electron-withdrawing groups on the nitrogen atom. These enamines are found to be suitable for a variety of further transformations.