CD46-targeted theranostics for Positron Emission Tomography and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma.
Anju WadhwaSinan WangBonell Patiño EscobarAnil Parsram BidkarKondapa Naidu BobbaEmily ChanNiranjan MeherScott BidlingmaierYang SuSuchi DhronaHuimin GengVishesh SarinHenry F VanBrocklinDavid M WilsonJiang HeLi ZhangVeronica SteriSandy W WongThomas G MartinYoungho SeoBin LiuArun P WiitaRobert Richard FlavellPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Our study showed that the CD46-targeted probe [89Zr]Zr-DFO-YS5 can successfully image CD46-expressing MM xenografts in murine models, and [225Ac]Ac-DOTA-YS5 can effectively inhibit the growth of MM. These results demonstrate that CD46 is a promising theranostic target for MM, with the potential for clinical translation.