Cardiac phenotype in familial partial lipodystrophy.
Abdelwahab Jalal EldinBarış AkıncıAndre Monteiro da RochaRasimcan MeralIlgin Yildirim SimsirSuleyman Cem AdiyamanEbru OzpelitNicole BhaveRamazan GenBanu Sarer YurekliNilufer OzdemirZeynep ŞiklarAdam H NeidertRita HenchMarwan K TayehJeffrey W InnisJose JalifeHakan OralElif Arioglu OralPublished in: Clinical endocrinology (2021)
Our results highlight the need for vigilant cardiac monitoring in FPLD, especially in patients with LMNA variants who have an increased risk of developing cardiac arrhythmias. In addition, hiPSC-CMs can be studied to understand the basic mechanisms for the arrhythmias in patients with lipodystrophy to understand the impact of specific mutations.