Biological and molecular effects of bromodomain and extra-terminal (BET) inhibitors JQ1, IBET-151, and IBET-762 in OSCC cells.

Federica BaldanLorenzo AllegriMilos LazarevicMio CatiaMaja MilosevicGiuseppe DamanteJelena M Milasin

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2019)

BET inhibitors induce both OSCC cell death and reduction of tumor aggressiveness. Molecular mechanisms of BET inhibition involve among others, MCM5 downregulation. Importantly, this study demonstrates for the first time the anti-tumoral effect of IBET-151 and IBET-762 in oral cancer.

Keyphrases

cell death
cell cycle arrest
induced apoptosis
signaling pathway
cell proliferation
single molecule