Neuroprotective Effects of Phytochemicals against Aluminum Chloride-Induced Alzheimer's Disease through ApoE4/LRP1, Wnt3/β-Catenin/GSK3β, and TLR4/NLRP3 Pathways with Physical and Mental Activities in a Rat Model.
Ahmed Mohsen Elsaid HamdanFatimah Hussain J AlharthiAhmed Hadi AlanaziSoad Z El-EmamSameh S ZaghloolKamel MetwallySana Abdulaziz AlbalawiYahia S AbduReda El-Sayed MansourHoda A SalemZakaria Y Abd ElmageedKarema Abu-ElfotuhPublished in: Pharmaceuticals (Basel, Switzerland) (2022)
The use of phytochemicals with PhM is a promising strategy for reducing AD by modulating Nrf2/HO-1, TLR4/NLRP3, APOE4/LRP1, and Wnt3/β-catenin/GSK-3β signaling pathways.
Keyphrases
- pi k akt
- cell proliferation
- signaling pathway
- cognitive decline
- epithelial mesenchymal transition
- toll like receptor
- inflammatory response
- mental health
- immune response
- high fat diet
- mild cognitive impairment
- oxidative stress
- high glucose
- diabetic rats
- physical activity
- stem cells
- nlrp inflammasome
- induced apoptosis
- nuclear factor
- low density lipoprotein
- drug induced
- endothelial cells
- type diabetes
- skeletal muscle