MicroRNA-Assisted Hormone Cell Signaling in Colorectal Cancer Resistance.
Crescenzo MassaroElham SafadehGiulia SguegliaHendrik G StunnenbergLucia AltucciCarmela Dell'AversanaPublished in: Cells (2020)
Despite substantial progress in cancer therapy, colorectal cancer (CRC) is still the third leading cause of cancer death worldwide, mainly due to the acquisition of resistance and disease recurrence in patients. Growing evidence indicates that deregulation of hormone signaling pathways and their cross-talk with other signaling cascades inside CRC cells may have an impact on therapy resistance. MicroRNAs (miRNAs) are small conserved non-coding RNAs thatfunction as negative regulators in many gene expression processes. Key studies have identified miRNA alterations in cancer progression and drug resistance. In this review, we provide a comprehensive overview and assessment of miRNAs role in hormone signaling pathways in CRC drug resistance and their potential as future targets for overcoming resistance to treatment.
Keyphrases
- gene expression
- signaling pathway
- cancer therapy
- induced apoptosis
- papillary thyroid
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- transcription factor
- stem cells
- single cell
- cell therapy
- epithelial mesenchymal transition
- squamous cell carcinoma
- cell proliferation
- peritoneal dialysis
- cell cycle arrest
- risk assessment
- bone marrow
- free survival
- case control