Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia.

Rakel Brendsdal ForthunMonica HellesøyAndré SulenReidun Kristin KopperudGry SjøholtØystein BruserudEmmet McCormackBjorn Tore Gjertsen

Published in: Journal of cancer research and clinical oncology (2019)

IFNα-2b and IFNα-Le showed potent and synergistic anti-leukemic effects with VPA in vitro but not in leukemic mouse and rat models in vivo. The absence of IFNα immune activation in lymphocyte subsets may potentially explain the limited in vivo anti-leukemic effect of IFNα-monotherapy in AML.

Keyphrases

dendritic cells
acute myeloid leukemia
immune response
peripheral blood
allogeneic hematopoietic stem cell transplantation
clinical trial
combination therapy
anti inflammatory
double blind