Drug-induced acute liver failure in children and adults: Results of a single-centre study of 128 patients.
Harshad C DevarbhaviMallikarjun PatilVishnu V ReddyRajvir SinghTarun JosephDeepak GangaPublished in: Liver international : official journal of the International Association for the Study of the Liver (2017)
Fourteen percent of DILI resulted in DIALF. ATD, AED, dapsone and antiretroviral drugs are most common agents. Spontaneous survival was only 34% with an even higher mortality with ATD. Non-ATD and non-APAP drugs had a better survival (51%).INR and MELD predicted mortality.
Keyphrases
- drug induced
- liver failure
- liver injury
- hepatitis b virus
- cardiovascular events
- young adults
- adverse drug
- risk factors
- human immunodeficiency virus
- hiv infected
- hiv aids
- type diabetes
- cardiovascular disease
- hepatitis c virus
- coronary artery disease
- south africa
- antiretroviral therapy
- acute respiratory distress syndrome
- electronic health record