Increased transcription of TSPO, HDAC2, and HDAC6 in the amygdala of males with alcohol use disorder.
Luana Martins De CarvalhoCorinde E WiersHui SunGene-Jack WangNora D VolkowPublished in: Brain and behavior (2020)
Our study is the first to find upregulated TSPO mRNA levels in AMY and PFC in postmortem brains from AUD consistent with neuroinflammation, and in the amygdala, they implicate epigenetic regulation of TSPO by HDAC2 and HDAC6.