Ginsenoside Rg3 nanoparticles with permeation enhancing based chitosan derivatives were encapsulated with doxorubicin by thermosensitive hydrogel and anti-cancer evaluation of peritumoral hydrogel injection combined with PD-L1 antibody.
Hao WuGuoli WeiLixia LuoLingchang LiYibo GaoXiaobin TanSen WangHaoxiao ChangYuxi LiuYingjie WeiJie SongZhenhai ZhangJiege HuoPublished in: Biomaterials research (2022)
The hydrogel encapsulating DOX and highly permeable Rg3-PNPs provided an efficient strategy for remodeling immunosuppressive tumor microenvironment and converting immune "cold" 4T1 into "hot" tumors.