Spatially segregated defects and IGF1-responsiveness of hilar and peripheral biliary organoids from a model of Alagille syndrome.

Afshan Iqbal Noémi K M van Hul Lenka Belicova Agustín A Corbat Simona Hankeova Emma Rachel Andersson

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

pICOs can be rescued by IGF1, hICOs are unresponsive, perhaps due to their hepatocyte-like state and/or expression of IGF transport components. IGF1 represents a potential therapeutic for peripheral bile ducts.

Keyphrases

binding protein
pi k akt
growth hormone
signaling pathway
chemotherapy induced