T2 measurement and quantification of cerebral white and gray matter aspartate concentrations in vivo at 3T: a MEGA-PRESS study.

MEGA-PRESS is the most common editing method used for low-concentration metabolites detection. Estimation of the absolute Asp concentrations has potential in many research applications, such as studying the processes underlying the reduction of N-acetyl aspartate as well as studying mitochondrial diseases etc. The T2 measurement method described has been successfully applied for edited Asp signals. This method can also be used for other strongly J-coupled signals.