Application and optimisation of the Comparison on Extreme Laboratory Tests (CERT) algorithm for detection of adverse drug reactions: Transferability across national boundaries.

Mun Yee ThamQing YePei San AngLiza Y FanDukyong Yoon Rae Woong ParkZheng Jye LingJames W YipBee Choo TaiStephen J W Evans Cynthia Sung

Published in: Pharmacoepidemiology and drug safety (2017)

We have demonstrated that the CERT algorithm can be applied across national boundaries. One modification (CERT400) was able to identify adverse drug reaction signals from laboratory data with reasonable PPV and sensitivity, which indicates potential utility as a supplementary pharmacovigilance tool.

Keyphrases

adverse drug
electronic health record
machine learning
quality improvement
deep learning
emergency department
drug induced
climate change
big data
neural network
artificial intelligence
data analysis
electron transfer