Study on Absorption, Distribution and Excretion of a New Candidate Compound XYY-CP1106 against Alzheimer's Disease in Rats by LC-MS/MS.
Zili GuoBianbian GaoMiaoliang FanLisha ChenChangjun ZhangXianrui LiangWeike SuYuanyuan XiePublished in: Molecules (Basel, Switzerland) (2023)
XYY-CP1106, a candidate compound synthesized from a hybrid of hydroxypyridinone and coumarin, has been shown to be remarkably effective in treating Alzheimer's disease. A simple, rapid and accurate high-performance liquid chromatography coupled with the triple quadrupole mass spectrometer (LC-MS/MS) method was established in this study to elucidate the pharmacokinetics of XYY-CP1106 after oral and intravenous administration in rats. XYY-CP1106 was shown to be rapidly absorbed into the blood ( T max , 0.57-0.93 h) and then eliminated slowly ( T 1/2 , 8.26-10.06 h). Oral bioavailability of XYY-CP1106 was (10.70 ± 1.72)%. XYY-CP1106 could pass through the blood-brain barrier with a high content of (500.52 ± 260.12) ng/g at 2 h in brain tissue. The excretion results showed that XYY-CP1106 was mainly excreted through feces, with an average total excretion rate of (31.14 ± 0.05)% in 72 h. In conclusion, the absorption, distribution and excretion of XYY-CP1106 in rats provided a theoretical basis for subsequent preclinical studies.
Keyphrases
- high performance liquid chromatography
- mass spectrometry
- tandem mass spectrometry
- high resolution
- simultaneous determination
- cognitive decline
- liquid chromatography
- multiple sclerosis
- high dose
- low dose
- solid phase extraction
- mesenchymal stem cells
- functional connectivity
- resting state
- cell therapy
- blood brain barrier
- quantum dots
- white matter
- ms ms
- gas chromatography