Maternal C-reactive protein and in vitro fertilization (IVF) cycles.
Fatemeh Diba-BagtashAzizeh Farshbaf-KhaliliAlyeh GhasemzadehLaura LotzAmir FattahiMahnaz ShahnaziRalf DittrichPublished in: Journal of assisted reproduction and genetics (2020)
Embryo implantation is accompanied by a potent inflammatory response, and a gradient of cytokines and chemokines produced by endometrial cells supports the embryo-endometrial interaction. C-reactive protein (CRP) serves as an early marker of inflammation and recent studies have illustrated that controlled ovarian hyperstimulation (COH) could increase its levels. Interestingly, a high chance of pregnancy has been reported in women who had an elevated CRP level on the day of embryo transfer. It seems an elevated systemic inflammation in the in vitro fertilization (IVF) cycle can increase the implantation and pregnancy rates. However, the results regarding the association of CRP with ART outcomes are controversial. Therefore, in this review, we aimed to describe how CRP levels change during a cycle of IVF treatment and which factors can potentially affect this pattern of change. Furthermore, the association of CRP with ART outcomes has been discussed.
Keyphrases
- pregnancy outcomes
- pregnant women
- inflammatory response
- induced apoptosis
- oxidative stress
- hiv infected
- endometrial cancer
- antiretroviral therapy
- cell cycle arrest
- type diabetes
- lipopolysaccharide induced
- cell proliferation
- cell death
- skeletal muscle
- toll like receptor
- preterm birth
- physical activity
- combination therapy
- anti inflammatory
- cervical cancer screening