Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator.
Anabela BorgesMariana SousaTamara R TodorovićNenad R FilipovićAlfonso T García-SosaPublished in: Molecules (Basel, Switzerland) (2018)
Pseudomonas aeruginosa is one of the most dreaded human pathogens, because of its intrinsic resistance to a number of commonly used antibiotics and ability to form sessile communities (biofilms). Innovative treatment strategies are required and that can rely on the attenuation of the pathogenicity and virulence traits. The interruption of the mechanisms of intercellular communication in bacteria (quorum sensing) is one of such promising strategies. A cobalt coordination compound (Co(HL)₂) synthesized from (E)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)-4-(p-tolyl)thiazole (HL) is reported herein for the first time to inhibit P. aeruginosa 3-oxo-C12-HSL-dependent QS system (LasI/LasR system) and underling phenotypes (biofilm formation and virulence factors). Its interactions with a possible target, the transcriptional activator protein complex LasR-3-oxo-C12-HSL, was studied by molecular modeling with the coordination compound ligand having stronger predicted interactions than those of co-crystallized ligand 3-oxo-C12-HSL, as well as known-binder furvina. Transition metal group 9 coordination compounds may be explored in antipathogenic/antibacterial drug design.
Keyphrases
- biofilm formation
- pseudomonas aeruginosa
- candida albicans
- cystic fibrosis
- transition metal
- staphylococcus aureus
- acinetobacter baumannii
- endothelial cells
- escherichia coli
- reduced graphene oxide
- gene expression
- emergency department
- antimicrobial resistance
- gold nanoparticles
- immune response
- inflammatory response
- anti inflammatory
- drug induced
- silver nanoparticles
- heat shock
- binding protein