Infection Is Not Required for Mucoinflammatory Lung Disease in CFTR-Knockout Ferrets.
Bradley H RosenT Idil Apak EvansShashanna R MollJaimie S GrayBo LiangXingshen SunYulong ZhangChandler W Jensen-CodyAnthony M SwatekWeihong ZhouNan HePavana G RottiScott R TylerNicholas W KeiserPreston J AndersonLeonard BrooksYalan LiR Marshall PopeMaheen RajputEric A HoffmanKai WangJ Kirk HarrisKalpaj R ParekhKatherine N Gibson-CorleyJohn F EngelhardtPublished in: American journal of respiratory and critical care medicine (2019)
These findings implicate mucoinflammatory processes in the CF lung as pathogenic in the absence of clinically apparent bacterial and fungal infections.