Tauroursodeoxycholic acid attenuates neuronal apoptosis via the TGR5/ SIRT3 pathway after subarachnoid hemorrhage in rats.

Huihui WuNini YuXia WangYina YangHui Liang

Published in: Biological research (2020)

Our findings demonstrate that TUDCA could attenuated neuronal apoptosis and improve neurological functions through TGR5/ SIRT3 signaling pathway after SAH. TUDCA may be an attractive candidate for anti-apoptosis treatment in SAH.

Keyphrases

oxidative stress
subarachnoid hemorrhage
cerebral ischemia
cell cycle arrest
endoplasmic reticulum stress
brain injury
signaling pathway
cell death
pi k akt
induced apoptosis
ischemia reperfusion injury
epithelial mesenchymal transition