Pelvic bone sarcomas, prognostic factors, and treatment: A narrative review of the literature.
Minna Katariina LaitinenMichael C ParryGuy V MorrisLee M JeysPublished in: Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society (2023)
Primary sarcomas of bone are rare malignant mesenchymal tumors. The most common bone sarcomas are osteosarcoma, Ewing's sarcoma, and chondrosarcoma. The prognosis has improved over the years, but bone sarcomas are still life-threatening tumors that need a multidisciplinary approach for diagnosis and treatment. Bone sarcomas arising in the pelvis present a unique challenge to orthopedic oncologists due to the absence of natural anatomical barriers, the close proximity of vital neurovascular structures, and the high mechanical demands placed on any pelvic reconstruction following the excision of the tumor. While radiotherapy has an important role especially in Ewing's sarcoma and chemotherapy for both Ewing's sarcoma and osteosarcoma, surgery remains the main choice of treatment for all three entities. While external hemipelvectomy has remained one option, the main aim of surgery is limb salvage. After complete tumor resection, the bone defect needs to be reconstructed. Possibilities to reconstruct the defect include prosthetic or biological reconstruction. The method of reconstruction is dependent on the location of tumor and the surgery required for its removal. The aim of this article is to give an insight into pelvic bone sarcomas, their oncological and surgical outcomes, and the options for treatment based on the authors' experiences.
Keyphrases
- bone mineral density
- minimally invasive
- soft tissue
- high grade
- bone regeneration
- bone loss
- rectal cancer
- prognostic factors
- coronary artery bypass
- stem cells
- squamous cell carcinoma
- early stage
- body composition
- coronary artery disease
- radiation therapy
- high resolution
- acute coronary syndrome
- combination therapy
- atrial fibrillation
- percutaneous coronary intervention
- mass spectrometry
- robot assisted
- radical prostatectomy
- surgical site infection