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Modulation of human induced neural stem cell-derived dopaminergic neurons by DREADD reveals therapeutic effects on a mouse model of Parkinson's disease.

Xueyao WangDeqiang HanTianqi ZhengJinghong MaZhiguo Chen
Published in: Stem cell research & therapy (2024)
iNSC-DAPs are a promising candidate for cell replacement therapy for Parkinson's disease. Remote DREADD-dependent activation of iNSC-DAP neurons significantly enhanced the beneficial effects on transplanted mice with Parkinson's disease.
Keyphrases
  • stem cells
  • mouse model
  • spinal cord
  • endothelial cells
  • type diabetes
  • oxidative stress
  • spinal cord injury
  • adipose tissue
  • insulin resistance
  • bone marrow