Fluorescence kinetics study of twice laser irradiation based HpD-PDT for nonmelanoma skin cancer.
Chunxiao LiPeiru WangDixin WangLei ShiZhongxia ZhouLinglin ZhangGuolong ZhangChengqian ChenXiuli L WangPublished in: Lasers in surgery and medicine (2022)
The present study reported a significant increase in FL intensities at 48 and 72 hours after i.v. administration of HpD in patients with nonmelanoma skin cancers, which indicated accumulation of HpD at the cancer site. Importantly, HpD was found to be safe for NMSC patients. After therapy, FL intensities decreased, which indicated expending and metabolization of HpD. Thus, the results of the present study highlighted the suitability of a twice red-light laser irradiation strategy for the application of HpD-PDT in nonmelanoma skin cancer treatment.